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Centrosomes are major microtubule-organizing centers of the cell. It is consisting of a pair of barrel-shaped structures called centriole, surrounded by a cloud of protein called pericentriolar material (PCM). These cellular structures are involved in spindle organization, cell migration and cell polarization. Centrosome organization is highly regulated during cell cycle and any defect in its structure or number leads to genomic instability and thereby cancers. Using a combination of cellular, molecular and biochemical approaches, we are interested in understanding the molecular details of centrosome organization in mammalian cells.
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Research Focus:
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Centrosome Biology
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Cilia
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Cancer Biology
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Microtubule Machinery
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